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Table 38 Anti-inflammatory activity of compounds (e5–e7) in formal in induced rat paw edema bioassay (sub-acute inflammatory model)

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds

Volume of edema (ml)a

0

1st day

8th day

e5

0.31 ± 0.01

0.51 ± 0.03b (44)c

0.68 ± 0.02b (31)

e6

0.35 ± 0.02

0.54 ± 0.01b (47)

0.67 ± 0.02b (40)

e7

0.33 ± 0.02

0.15 ± 0.01b (50)

0.67 ± 0.02b (37)

Control

0.32 ± 0.01

0.68 ± 0.01

0.86 ± 0.03

Diclofenac

0.32 ± 0.02

0.52 ± 0.02b (44)

0.64 ± 0.02b (40)

  1. aValues are expressed as mean ± S.E. (Number of animals N = 5 rats)
  2. bSignificantly different compared to corresponding control P ≤ 0.05
  3. cBetween parentheses (percentage anti-inflammatory activity %)