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Table 38 Anti-inflammatory activity of compounds (e5e7) in formal in induced rat paw edema bioassay (sub-acute inflammatory model)

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds Volume of edema (ml)a
0 1st day 8th day
e5 0.31 ± 0.01 0.51 ± 0.03b (44)c 0.68 ± 0.02b (31)
e6 0.35 ± 0.02 0.54 ± 0.01b (47) 0.67 ± 0.02b (40)
e7 0.33 ± 0.02 0.15 ± 0.01b (50) 0.67 ± 0.02b (37)
Control 0.32 ± 0.01 0.68 ± 0.01 0.86 ± 0.03
Diclofenac 0.32 ± 0.02 0.52 ± 0.02b (44) 0.64 ± 0.02b (40)
  1. aValues are expressed as mean ± S.E. (Number of animals N = 5 rats)
  2. bSignificantly different compared to corresponding control P ≤ 0.05
  3. cBetween parentheses (percentage anti-inflammatory activity %)