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Table 33 In vitro antimalarial activity of AQ-furfural-2-carbaldehyde-pyrimidine hybrids

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compound P. falciparum D6 P. falciparum W2 VERO cells Resistance index
IC50 (µM) (SI) IC50 (µM) (SI)
d4 0.038 ± 0.000 > 263.15 0.040 ± 0.001 > 250.0 NC 1.05
Chloroquine 0.011 ± 0.004 > 909.09 0.317 ± 0.051 > 31.54 NC 28.81
Pyrimethamine 0.009 ± 0.003 > 1111.1 NA NC
Artemisinin 0.045 ± 0.001 > 222.22 0.023 ± 0.001 434.78 NC 0.511