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Table 25 In vitro cytotoxicity of most active compounds

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds

IC50 values (in µM)

A549

MCF7

DU145

HeLa

b26

4.1 ± 0.12

4.7 ± 0.18

b27

5.7 ± 0.22

24.7 ± 0.16

6.3 ± 0.21

22.7 ± 0.11

b28

4.2 ± 0.31

37.2 ± 0.31

5.8 ± 0.14

34.3 ± 0.32

5-Fluorouracil

1.3 ± 0.11

1.4 ± 0.09

1.5 ± 0.12

1.3 ± 0.14