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Table 4 Antibacterial activity of synthesized compounds (3ak and 3lp) against Gram positive and Gram negative bacteria

From: Palladium(0) catalyzed Suzuki cross-coupling reaction of 2,5-dibromo-3-methylthiophene: selectivity, characterization, DFT studies and their biological evaluations

Entry Product no % inhibition (50 μg/ml)
P. aeruginosa B. subtilis E. coli S. aureus S. typhi
1 3a 67.3 ± 0.76 *** 94.5 ± 0.09 33.9 ± 0.37 27.6 ± 0.08
2 3b 39.2 ± 0.45 *** 50.1 ± 0.29 9.57 ± 0.15 5.58 ± 0.05
3 3c *** *** *** *** ***
4 3d 34.9 ± 0.27 *** 7.8 ± 0.09 *** 8.34 ± 0.23
5 3e *** *** *** *** **
6 3f *** *** *** *** ***
7 3g *** *** *** *** ***
8 3h 37.6 ± 0.26 *** 50.4 ± 0.45 *** 12.0 ± 0.02
9 3i 41.1 ± 0.47 *** 70.4 ± 0.78 *** 2.59 ± 0.01
10 3j *** *** *** *** ***
11 3k 50.5 ± 0.58 *** 72.5 ± 0.87 20.1 ± 0.06 17.3 ± 0.05
12 3 l *** *** *** *** ***
13 3m *** *** *** *** ***
14 3n 20.8 ± 0.17 *** 30.6 ± 0.26 *** *
15 3o *** *** *** *** ***
16 3p *** *** *** *** ***
17 Control 100 ± 1.28 100 ± 1.21 100 ± 1.01 100 ± 0.99 100 ± 0.99
  1. *** Showed no activity. The results are average ± SD of triplicate experiments p < 0.05. Streptomycin was used as control standard drug