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Table 4 Screening of the reaction conditions to optimize the acetalization process

From: Synthesis, structural determination and antimicrobial evaluation of two novel CoII and ZnII halogenometallates as efficient catalysts for the acetalization reaction of aldehydes

Entry

Complex (mol%)

MeOH (mL)

Temperature (°C)

Yield (%)a

1

1 (2)

0.25

r.t.

65

2

1 (4)

0.25

r.t.

78

3

1 (6)

0.25

r.t.

78

4

1 (4)

0.50

r.t.

59

5

1 (4)

0.25

40

92

6

2 (2)

0.25

r.t.

63

7

2 (4)

0.25

r.t.

83

8

2 (6)

0.25

r.t.

71

9

2 (4)

0.50

r.t.

67

10

2 (4)

0.25

40

97

  1. Otherwise indicated: a mixture of aldehyde 3a (0.323 mmol) and catalysts 1 or 2 (4 mol%) in 0.25 mL MeOH, was stirred at 40 °C for 24 h. After this time the reaction crudes were analysed by 1H NMR
  2. aYields of 4a [61] determined by 1H-NMR spectroscopy
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BMC Chemistry

ISSN: 2661-801X

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