Table 5 Determination of Flutamide in its pharmaceutical formulation by the proposed methods, application of standard addition technique
From: Determination of flutamide and two major metabolites using HPLC–DAD and HPTLC methods
Pharmaceutical formulation | HPTLC method | HPLC method | ||||||
|---|---|---|---|---|---|---|---|---|
Taken (µg/band) | Founda % ± % RSD | Added (µg/band) | Recoveryb % | Taken (µg/mL) | Founda % ± %RSD | Added (µg/mL) | Recoveryb % | |
Cytomed® tablets labeled to contain 250 mg flutamide/tablet | 1.00 | 101.75 ± 0.975 | 0.60 | 100.63 | 15.00 | 102.02 ± 1.002 | 10.00 | 100.90 |
1.00 | 97.00 | 12.00 | 100.47 | |||||
1.50 | 99.0 | 15.00 | 98.13 | |||||
Mean ± SD | 98.82 ± 1.818 | Mean ± SD | 99.52 ± 1.385 | |||||