Table 1 Structural features of the designed inhibitors and predicted pMIC values
Designed inhibitor | R group | Predicted log1/MIC | Designed inhibitor | R group | Predicted pMIC |
|---|---|---|---|---|---|
1 |
| − 4.47 | 12 |
| − 3.46 |
2 |
| − 3.84 | 13 |
| − 0.90 |
3 |
| − 3.19 | 14 |
| − 2.93 |
4 |
| − 3.41 | 15 |
| − 1.85 |
5 |
| − 2.62 | 16 |
| − 2.29 |
6 |
| − 2.78 | 17 |
| − 3.23 |
7 |
| 0.65 | 18 |
| 0.44 |
8 |
| 0.19 | 19 |
| − 2.2 |
9 |
| − 0.13 | 20 |
| − 3.88 |
10 |
| 0.58 | 21 |
| − 4.05 |
11 |
| − 2.76 | 22 |
| − 6.8 |
