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Scheme 1 | Chemistry Central Journal

Scheme 1

From: Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine

Scheme 1

Scheme for the synthesis of 1,3,5-triazine (s-triazine) derivatives (7, 13 and 18). Regents: (a) p-nitroaniline, K2CO3 in THF, (b) 1-chloro-4-ethylpiperazine, K2CO3, 18-Crown-6 in dry THF (refluxed for 2.5 h), (c) 1-chloro-4-ethylpiperazine, K2CO3, 18-Crown-6 in dry CH3CN (refluxed for 3 h), (d) 3-(chloroamino)phenol, K2CO3, 18-Crown-6 in dry CH3CN (refluxed for 3 h)

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