Table 4 The pharmacokinetic parameters of lesinurad in rat plasma after oral or intravenous administration
From: Determination of lesinurad in rat plasma by a UHPLC–MS/MS assay
Parameter | Unit | Lesinurad (mean ± SD) | |
|---|---|---|---|
iv 5 mg/kg | po 20 mg/kg | ||
AUC(0–t) | µg/L h | 46,219.33 ± 5420.8 | 106,044.73 ± 32,137.3 |
AUC(0–∞) | µg/L h | 46,541.72 ± 32,232.5 | 106,613.55 ± 32,232.5 |
t 1/2 | h | 3.92 ± 1.6 | 3.22 ± 0.4 |
T max | h | 0.14 ± 0.1 | 2.46 ± 1.7 |
V | L/kg | 0.61 ± 0.2 | 0.94 ± 0.3 |
CL | L/h/kg | 0.11 ± 0.0 | 0.20 ± 0.1 |
C max | µg/L | 12,441.84 ± 1694.2 | 16,719.45 ± 2966.5 |
MRT(0–t) | h | 3.39 ± 0.3 | 5.06 ± 0.6 |
MRT(0–∞) | h | 3.58 ± 0.3 | 5.19 ± 0.6 |
Absolute bioavailability | 57.36% | ||