Table 1 Effect of compounds 1–5 on TNF-α, IL-1β, PGE2, COX-2,TGF-β1 levels
Group | TNF-α (pg/mL) | IL-1β (pg/mL) | PGE2 (pg/mL) | COX-2 (pg/mL) | TGF-β1 (pg/mL) |
|---|---|---|---|---|---|
Control | 91.4 ± 6.1** | 89.3 ± 7.2** | 57.2 ± 9.3** | 17.1 ± 3.7** | 84.8 ± 9.9** |
Negative control | 173.8 ± 11.2 | 160.3 ± 10.1 | 130.2 ± 6.9 | 41.4 ± 1.9 | 133.1 ± 10.2 |
Cernilton | 121.1 ± 10.5** | 132.4 ± 9.7** | 80.3 ± 5.7** | 20.3 ± 2.4** | 119.4 ± 11.7* |
1 | 101.7 ± 9.9** | 124.8 ± 8.0** | 119.7 ± 10.9* | 26.8 ± 4.1** | 101.6 ± 9.7** |
2 | 169.3 ± 11.7 | 156.7 ± 12.6 | 128.1 ± 11.7 | 39.7 ± 8.5 | 131.1 ± 12.2 |
3 | 161.1 ± 14.5 | 151.9 ± 10.3 | 125.7 ± 10.3 | 37.8 ± 6.2 | 129.8 ± 11.5 |
4 | 118.6 ± 10.3** | 147.5 ± 11.2* | 117.4 ± 8.3** | 30.3 ± 1.8** | 120.3 ± 11.4* |
5 | 170.1 ± 9.4 | 159.9 ± 12.7 | 129.1 ± 11.9 | 40.1 ± 5.9 | 130.6 ± 10.3 |