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Table 1 Inhibition effect of the compounds 4, 5a5q against Xoo and Rs

From: Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold

Compd. R Xoo Rs
100 μg/mL 50 μg/mL 100 μg/mL 50 μg/mL
2 84.5 ± 3.9 54.6 ± 8.5 46.5. ± 9.7 28.1 ± 7.8
3a H 84.9 ± 5.8 60.1 ± 2.5 36.0 ± 2.6 32.4 ± 6.1
3b 4-NO2Ph 81.4 ± 4.6 65.2 ± 9.0 81.5 ± 6.7 60.2 ± 6.9
3c 2-MePh 47.2 ± 1.5 25.9 ± 3.7 49.3 ± 6.7 30.3 ± 3.8
3d 4-ClPh 99.6 ± 0.1 90.7 ± 4.0 64.3 ± 8.8 30.4 ± 4.1
3e Me 58.2 ± 5.1 27.4 ± 5.4 75.7 ± 8.1 65.5 ± 9.9
3f 2-ClPh 87.3 ± 2.5 82.6 ± 2.6 69.3 ± 0.8 46.5 ± 9.1
3g 2-FPh 79.7 ± 3.6 21.0 ± 4.9 45.2 ± 5.9 38.3 ± 2.4
3h 4-OMePh 37.3 ± 6.2 15.5 ± 8.9 28.1 ± 7.6 27.1 ± 6.0
3i 2,4-di-ClPh 77.5 ± 1.4 68.2 ± 5.4 64.3 ± 6.1 52.1 ± 2.8
3j 3-NO2Ph 30.0 ± 1.2 79.8 ± 9.7 45.2 ± 8.3 31.1 ± 4.3
3k 4-BrPh 47.3 ± 4.7 23.3 ± 7.5 26.4 ± 2.6 10.7 ± 1.6
3l 2-BrPh 50.7 ± 1.9 31.6 ± 4.5 24.0 ± 4.7 16.2 ± 0.7
3m 2-Cl-thiazol-5-yl 99.4 ± 3.9 80.8 ± 3.7 26.3 ± 3.2 25.0 ± 6.6
3n Ph 38.3 ± 4.5 17.7 ± 0.1 45.3 ± 5.6 44.7 ± 5.1
3o 4-MePh 52.6 ± 3.3 37.6 ± 5.5 65.4 ± 1.7 52.1 ± 5.7
3p Pyridin-3-yl 84.3 ± 3.8 71.2 ± 5.3 38.0 ± 6.2 12.8 ± 6.0
Myricetin a 40.1 ± 8.3 21.0 ± 5.6 28.6 ± 2.2 17.5 ± 3.3
Thiadiazole-copper a 52.4 ± 2.0 28.7 ± 4.1 46.7 ± 2.0 32.2 ± 2.1
  1. Average of three replicates
  2. a Thiadiazole-copper and myricetin were used for comparison of antibacterial activity