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Table 2 PK parameters of the key compoundsa

From: Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents

Code

Tmax (h)

Cmax (μM)

AUC 0–t (μM h)

AUC 0–∞ (μM h)

MRT (h)

t1/2 (h)

7a

0.42

0.62

1.55

1.58

3.55

4.69

7b

1.00

0.79

2.32

2.36

4.47

3.39

  1. aPK parameters were calculated in rats after single oral dosing of 25 mg kg−1, (n = 3) by non-compartmental analysis using WinNonlin, version 5.3
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BMC Chemistry

ISSN: 2661-801X

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