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Table 1 Synthesis of N-phenylamides 17

From: Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl4

Entry

R1

R2

R3

 

Product

Yield (%)a

a

C6H5

H

C6H5

1

98

b

4-NO2–C6H4

H

C6H5

2

98

c

4-CH3O–C6H4

H

C6H5

3

95

d

4-Cl–C6H4

H

C6H5

4

95

e

C6H5CH2

H

C6H5

5

95

f

C6H5CH=CH

H

C6H5

6

91

g

C15H31

H

C6H5

7

88

  1. aIsolated yields