Table 2 Optimization of reaction ratio
From: The development of an effective synthetic route of lesinurad (RDEA594)
Entry | 4-Cyclopropylnaphthalen-1-amine(eq.) | TCDI (eq.) | Yield % |
|---|---|---|---|
1 | 1 | 1 | 72.9 |
2 | 1 | 1.5 | 83.6 |
3 | 1 | 2 | 83.5 |
4 | 1 | 2.5 | 82.7 |
From: The development of an effective synthetic route of lesinurad (RDEA594)
Entry | 4-Cyclopropylnaphthalen-1-amine(eq.) | TCDI (eq.) | Yield % |
|---|---|---|---|
1 | 1 | 1 | 72.9 |
2 | 1 | 1.5 | 83.6 |
3 | 1 | 2 | 83.5 |
4 | 1 | 2.5 | 82.7 |