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Table 1 Antibacterial activity of synthesized compounds (zone of inhibition in diameter in mm)

From: Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate

Tested microorganisms comp. no

Gram positive bacteria inhibition zone diameter in mm and (%) value

Gram negative bacteria inhibition zone diameter in mm and (%) value

Streptococcus pneumoniae

Bacillus subtilis

Pseudomonas aeruginosa

Escherichia coli

St.

Ampicillin

Gentamicin

23.8 ± 0.2

32.4 ± 0.3

17.3 ± 0.1

19.9 ± 0.3

2

16.9 ± 0.58 (71.0%)

18.2 ± 0.44 (56.2%)

10.7 ± 0.34 (61.8%)

11.9 ± 0.63 (59.8%)

3

12.9 ± 0.63 (54.2%)

13.2 ± 0.58 (40.7%)

11.8 ± 0.36 (67.2%)

10.8 ± 0.44 (54.3%)

4

16.7 ± 0.54 (70.2%)

17.4 ± 0.63 (53.7%)

14.1 ± 0.52 (81.5%)

13.2 ± 0.47 (66.3%)

5

19.3 ± 0.67 (81.1%)

14.6 ± 0.57 (45.1%)

13.6 ± 0.42 (78.6%)

14.5 ± 0.54 (72.9%)

6

16.5 ± 0.78 (69.3%)

17.7 ± 0.63 (54.6%)

14.2 ± 0.56 (82.1%)

15.7 ± 0.52 (78.9%)

7a

18.2 ± 0.44 (76.5%)

20.3 ± 0.35 (62.7%)

17.1 ± 0.34 (98.8%)

20.3 ± 0.29 (102%)

7b

23.8 ± 0.2 (100%)

32.4 ± 0.3 (100%)

17.3 ± 0.1 (100%)

19.9 ± 0.3 (100%)

8

23.8 ± 0.2 (100%)

32.4 ± 0.3 (100%)

17.3 ± 0.1 (100%)

19.9 ± 0.3 (100%)

9

16.4 ± 0.52 (68.9%)

13.9 ± 0.39 (42.9%)

13.2 ± 0.38 (76.3%)

12.8 ± 0.38 (64.3%)

10

12.8 ± 0.34 (53.8%)

15.4 ± 0.53 (47.5%)

11.9 ± 0.32 (67.8%)

11.6 ± 0.35 (58.3%)

11a

14.6 ± 0.58 (61.3%)

14.3 ± 0.58 (44.1%)

10.2 ± 0.32 (59.0%)

9.4 ± 0.44 (47.2%)