Table 6 Stress testing results of brimonidine tartrate in stock solution
Nature of stress | Storage conditions | Time (h) | Amount [remaining ± SD (%)] (PP) | Extent of decomposition |
|---|---|---|---|---|
5 M HCl | 40 °C | 24 | 96.5 ± 0.8 (999.74) | A little |
5 M NaOH | 40 °C | 2 | 95.6 ± 2.3 (999.98) | A little |
6% H2O2 | 40 °C | 24 | 42.4 ± 0.5 (999.74) | Substantial |
Thermal | 40 °C | 120 | 99.3 ± 0.2 (999.99) | None |
40 °C | 240 | 99.2 ± 0.2 (999.99) | None | |
Dry heat | 105 °C | 7 | 99.4 ± 0.2 (999.85) | None |
Photolytic | 12 million lux hours and 200 W h/m2 | 99.3 ± 0.2 (999.99) | None | |