Design, synthesis and antimicrobial evaluation of pyrimidin-2-ol/thiol/amine analogues

BMC Chemistry

Table 1 The physicochemical properties of synthesized 4-(substituted phenyl)-6-(4-nitrophenyl) pyrimidin-2-ol/thiol/amine derivatives

Compounds	M. formula	M. weight	M.pt. (°C)	R_f value^a	% Yield
Physicochemical properties
1.	C₁₆H₁₁ClN₄O₂	326	80–82	0.45	75.00
2.	C₁₆H₁₀ClN₃O₂S	343	61–63	0.57	84.72
3.	C₁₆H₁₁ClN₄O₂	326	76–78	0.60	78.78
4.	C₁₆H₁₀ClN₃O₂S	343	90–92	0.62	72.54
5.	C₁₆H₁₁ClN₄O₂	326	122–124	0.58	82.22
6.	C₁₆H₁₀ClN₃O₂S	343	63–65	0.56	75.00
7.	C₁₆H₁₀ClN₃O₃	327	127–129	0.60	84.72
8.	C₁₇H₁₄N₄O₃	322	66–68	0.51	73.43
9.	C₁₇H₁₄N₄O₃	322	89–91	0.56	76.47
10.	C₁₆H₁₀BrN₃O₃S	404	59–61	0.61	81.81
11.	C₁₆H₁₁BrN₄O₂	371	153–155	0.41	64.00
12.	C₁₆H₁₀ClN₄O₂	361	87–89	0.42	87.61
13.	C₁₈H₁₆N₄O₃	336	156–158	0.45	77.38

ISSN: 2661-801X