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Table 5 VNT stability data in RLMs matrix under different conditions

From: Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

Nominal concentration (ng/mL) Mean (ng/mL) Recovery % Precision (% RSD)
Room temp. for 8 h
 20 19.35 ± 0.28 96.75 1.45
 150 148.71 ± 1.62 99.14 1.09
 400 396.96 ± 3.15 99.24 0.79
Three freeze–thaw cycles
 20 19.46 ± 0.36 97.31 1.86
 150 150.47 ± 1.16 100.32 0.77
 400 399.58 ± 6.02 99.89 1.51
Stored at 4 °C for 24 h
 20 19.43 ± 0.33 97.14 1.70
 150 150.26 ± 0.98 100.17 0.65
 400 398.08 ± 4.73 99.52 1.19
Stored at −20 °C for 30 days
 20 19.16 ± 0.59 95.78 3.08
 150 149.80 ± 1.84 99.87 1.23
 400 398.55 ± 5.36 99.64 1.34