Skip to main content

Table 2 The in vitro inhibitory activity of tested compounds against tumor cell lines expressed as IC50 values (μg/mL) ±standard deviation from three replicates

From: Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents

Tested compounds R Ar′ Tumor cell lines
A-549 HepG2
6a COCH3 Ph 22.9 ± 0.9 5.60 ± 0.8
6b COCH3 4-MeC6H4 38.5 ± 1.2 44.4 ± 1.3
6c COOEt Ph 23.3 ± 0.9 22.4 ± 0.9
6d 2-Thienyl 4-NO2C6H4 30.6 ± 1.1 35.9 ± 1.4
9 22.6 ± 0.8 5.67 ± 1.2
13a 2-Naphthyl 4.47 ± 0.3 8.03 ± 1.1
13b 2-Furyl 3.46 ± 0.6 4.67 ± 0.9
18a Ph 32.7 ± 1.2 22.4 ± 1.1
18b 4-MeC6H4 19.1 ± 1.1 6.67 ± 1.3
18c 4-ClC6H4 18.2 ± 0.9 21.8 ± 0.9
19 21.3 ± 0.8 23.1 ± 1.1
21a Ph 3.10 ± 0.8 23.9 ± 1.1
21b 4-MeC6H4 33.6 ± 0.9 43.4 ± 0.8
23a 2-Thienyl 4-NO2C6H4 27.9 ± 1.1 34.4 ± 0.9
23b Ph Ph 23.4 ± 1.2 5.67 ± 1.7
Cisplatin 0.95 ± 0.23 1.4 ± 0.37