Table 2 The in vitro inhibitory activity of tested compounds against tumor cell lines expressed as IC50 values (μg/mL) ±standard deviation from three replicates 
Tested compounds | R | Ar′ | Tumor cell lines | |
|---|---|---|---|---|
A-549 | HepG2 | |||
6a | COCH3 | Ph | 22.9 ± 0.9 | 5.60 ± 0.8 |
6b | COCH3 | 4-MeC6H4 | 38.5 ± 1.2 | 44.4 ± 1.3 |
6c | COOEt | Ph | 23.3 ± 0.9 | 22.4 ± 0.9 |
6d | 2-Thienyl | 4-NO2C6H4 | 30.6 ± 1.1 | 35.9 ± 1.4 |
9 | – | – | 22.6 ± 0.8 | 5.67 ± 1.2 |
13a | – | 2-Naphthyl | 4.47 ± 0.3 | 8.03 ± 1.1 |
13b | – | 2-Furyl | 3.46 ± 0.6 | 4.67 ± 0.9 |
18a | – | Ph | 32.7 ± 1.2 | 22.4 ± 1.1 |
18b | – | 4-MeC6H4 | 19.1 ± 1.1 | 6.67 ± 1.3 |
18c | – | 4-ClC6H4 | 18.2 ± 0.9 | 21.8 ± 0.9 |
19 | – | – | 21.3 ± 0.8 | 23.1 ± 1.1 |
21a | – | Ph | 3.10 ± 0.8 | 23.9 ± 1.1 |
21b | – | 4-MeC6H4 | 33.6 ± 0.9 | 43.4 ± 0.8 |
23a | 2-Thienyl | 4-NO2C6H4 | 27.9 ± 1.1 | 34.4 ± 0.9 |
23b | Ph | Ph | 23.4 ± 1.2 | 5.67 ± 1.7 |
Cisplatin | – | – | 0.95 ± 0.23 | 1.4 ± 0.37 |