Table 3 The antitumor activities of the tested compounds expressed as IC50 values and compared with reference standard drugs evaluated on breast and liver cancer cell lines
Tested compounds | IC50 values (µg/mL) against tumor cell lines | |
|---|---|---|
MCF-7 | HepG2 | |
3a | >200 | 153.1 ± 2.3 |
3b | NA | NA |
3c | 41.9 ± 1.7 | 18.8 ± 1.1 |
3d | >200 | 150.9 ± 3.7 |
3e | >200 | >200 |
4a | 22.3 ± 1.5 | 4.8 ± 0.6 |
4b | 46.1 ± 1.6 | 24.5 ± 1.2 |
4c | 63.8 ± 1.2 | 45.2 ± 1.4 |
4d | >200 | >200 |
5-flourouracil | 5.2 ± 0.5 | 4.9 ± 0.3 |
Cisplatin | 19.1 ± 0.7 | 18.8 ± 0.6 |