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Table 1 Cytotoxic activity of the tested compounds against HepG2

From: A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety

Sample number R X IC50 (μM)
Doxorubicin 0.72 ± 0.13
6a Ac H 9.89 ± 0.19
6b Ac 4-Me 39.06 ± 0.24
6c Ac 4-Cl 1.29 ± 0.27
6d Ac 4-OMe 64.35 ± 0.14
6e Ac 3-Cl 4.03 ± 0.19
6f Ac 4-Br 1.88 ± 0.08
6g Ac 2,4-Cl2 1.06 ± 0.12
12a CO2Et H 4.70 ± 0.16
12b CO2Et 4-Me 32.4 ± 0.19
12c CO2Et 4-Cl 0.91 ± 0.20
12d CO2Et 2,4-Cl2 0.82 ± 0.13
18a CONHPh H 6.79 ± 0.11
18b CONHPh 2,4-Cl2 1.25 ± 0.18