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Table 2 The EC50 of the ligustrazine-vanillic acid amide derivatives for protecting damaged PC12 cells

From: Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells

Compd

Proliferation rate (%)

EC50 (μM)a

60 μM

30 μM

15 μM

7.5 μM

3.75 μM

VA-01

81.75 ± 2.34

49.05 ± 4.07

43.15 ± 3.11

21.25 ± 1.25

22.77 ± 7.27

18.74 ± 1.94

VA-02

7.38 ± 0.95

12.55 ± 1.50

−0.47 ± 1.97

−11.43 ± 2.05

−10.48 ± 1.68

>100

VA-03

25.50 ± 1.48

21.42 ± 1.35

18.63 ± 0.82

13.34 ± 1.68

7.36 ± 1.73

52.48 ± 2.0

VA-04

46.60 ± 2.14

40.99 ± 3.08

41.49 ± 2.89

23.64 ± 2.32

6.88 ± 1.89

29.61 ± 0.78

VA-05

37.17 ± 2.17

31.36 ± 3.78

25.65 ± 2.05

21.54 ± 2.19

17.11 ± 1.51

36.61 ± 1.97

VA-06

89.81 ± 3.02

51.80 ± 5.61

29.51 ± 4.15

17.32 ± 6.10

15.78 ± 3.01

17.39 ± 1.34

VA-07

8.79 ± 2.27

53.07 ± 2.41

47.15 ± 1.31

7.42 ± 1.00

−5.52 ± 2.14

60.20 ± 25.70

VA-08

52.64 ± 2.94

29.29 ± 2.93

23.41 ± 1.71

18.50 ± 3.61

26.69 ± 5.58

33.62 ± 3.96

VA-09

49.34 ± 1.80

41.80 ± 0.81

41.56 ± 1.51

23.14 ± 2.78

14.05 ± 3.78

27.90 ± 1.65

VA-10

16.33 ± 1.60

33.99 ± 2.61

12.56 ± 4.21

15.66 ± 4.06

15.60 ± 5.67

48.79 ± 3.76

VA-11

32.99 ± 2.82

23.38 ± 2.92

15.20 ± 2.54

11.09 ± 0.67

14.44 ± 4.85

47.85 ± 1.84

VA-12

−71.58 ± 2.70

−59.50 ± 3.91

−35.73 ± 3.44

−11.99 ± 4.56

13.86 ± 2.28

>100

VA-13

−277.39 ± 4.12

−292.67 ± 10.71

−297.34 ± 12.0

−298.64 ± 8.39

−296.33 ± 11.32

>100

VA-14

15.86 ± 1.47

12.13 ± 1.17

8.64 ± 0.83

5.51 ± 0.69

2.69 ± 0.72

71.66 ± 2.12

VA-15

−198.39 ± 4.52

−60.74 ± 3.21

88.57 ± 7.11

48.83 ± 5.28

45.01 ± 8.01

>100

VA-16

−23.15 ± 3.05

−13.96 ± 1.49

−14.86 ± 2.64

−14.51 ± 1.40

2.99 ± 1.08

>100

VA-17

69.41 ± 4.00

52.29 ± 3.05

32.78 ± 0.96

18.63 ± 0.81

10.12 ± 0.59

24.73 ± 1.37

VA-18

5.32 ± 1.11

12.04 ± 0.44

15.96 ± 1.05

15.27 ± 0.74

−2.97 ± 0.85

71.92 ± 1.07

VA-19

15.21 ± 3.12

13.89 ± 2.96

8.23 ± 1.31

8.61 ± 1.45

10.52 ± 2.03

65.72 ± 2.93

VA-20

25.14 ± 4.22

17.38 ± 0.21

15.87 ± 1.05

15.12 ± 0.65

8.97 ± 0.49

53.74 ± 1.69

TMP

14.44 ± 0.76

12.24 ± 0.66

11.82 ± 0.45

10.80 ± 0.43

9.65 ± 0.71

64.35 ± 1.47

T-VA

127.27 ± 3.70

118.60 ± 7.47

88.59 ± 2.28

51.49 ± 1.14

31.01 ± 0.94

4.29 ± 0.47

  1. aMean value ± standard deviation from three independent experiments
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BMC Chemistry

ISSN: 2661-801X

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