Design, synthesis and biological potentials of novel tetrahydroimidazo[1,2-a]pyrimidine derivatives

BMC Chemistry

Table 2 Antimicrobial activity (MIC = µM/ml) of the synthesized analogous

Comp.	Minimum inhibitory concentration (MIC)
	Bacterial strains			Fungal strains
	S. aureus	B. subtilis	E. coli	C. albicans	A. niger
1	2.19	2.19	2.19	2.19	1.09
2	4.19	2.10	2.10	1.05	1.05
3	2.27	2.27	2.27	1.13	1.13
4	4.33	4.33	8.67	2.17	1.08
5	9.07	1.13	9.07	2.27	1.13
6	2.27	2.27	2.27	2.27	1.13
7	2.28	1.14	2.28	2.28	1.14
8	2.39	2.39	2.39	2.39	1.20
9	2.26	2.26	2.26	2.26	1.13
10	2.18	2.18	2.18	2.18	1.09
11	2.33	1.17	2.33	2.33	1.17
12	2.14	2.14	2.14	2.14	2.14
13	9.33	2.33	9.33	2.33	2.33
14	2.14	2.14	2.14	2.14	2.14
15	4.16	1.04	2.08	1.04	1.04
16	4.66	1.17	2.33	2.33	2.33
17	2.34	1.17	2.34	2.34	1.17
18	4.63	0.58	2.31	2.31	2.31
19	2.47	1.24	2.47	2.47	1.24
20	2.31	1.16	2.31	1.16	2.31
21	2.21	1.10	1.10	1.10	1.10
22	2.39	2.39	2.39	1.20	1.20
23	4.63	1.16	2.31	2.31	2.31
24	2.35	1.17	2.35	1.17	1.17
Std.	0.47^a	0.47^a	0.47^a	0.50^b	0.50^b

ISSN: 2661-801X