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Table 4 Thiol concentrations (×10−6 mol L−1) of different incubation media at hour 70 in the simulated colon condition

From: Colon targeted drug delivery of branch-chained disulphide cross-linked polymers: design, synthesis, and characterisation studies

Incubation medium P10 P11 P12 P15 P21 P51
Bacteria only (1) 0.344 ± 0.076 0.151 ± 0.035 0.157 ± 0.007 0.299 ± 0.101 0.161 ± 0.019 0.146 ± 0.026
Polymer only (2) 2.509 ± 0.179 5.117 ± 0.537 8.212 ± 0.837 9.263 ± 0.151 3.791 ± 0.471 3.244 ± 0.357
Polymer + bacteria (3) 5.602 ± 0.159 20.288 ± 1.468 34.419 ± 0.541 56.898 ± 2.822 14.211 ± 0.675 7.915 ± 0.585
Statistical analysis p < 0.05 p < 0.05 p < 0.05 p < 0.05 p < 0.05 p < 0.05
Dunnett (2-sided) (significant) 1 & 3 1 & 3 1 & 3 1 & 3 1 & 3 1 & 3
2 & 3 2 & 3 2 & 3 2 & 3 2 & 3 2 & 3
  1. Mean ± SD, N = 3. The incubation medium containing polymer + bacteria (3) is the control sample