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Table 3 Final thiol concentration (×10−6 mol L−1) of each simulated condition, mean ± SD, n = 3

From: Colon targeted drug delivery of branch-chained disulphide cross-linked polymers: design, synthesis, and characterisation studies

Incubation medium

P10

P11

P12

P15

P21

P51

Gastric (1)

1.642 ± 0.249

3.302 ± 0.378

3.756 ± 0.308

4.921 ± 0.264

2.851 ± 0.256

2.478 ± 0.923

Intestine (2)

1.856 ± 0.254

3.147 ± 0.377

3.874 ± 0.459

6.113 ± 0.678

2.641 ± 0.269

2.349 ± 0.799

Colon (3)

5.602 ± 0.159

20.288 ± 1.468

34.419 ± 0.541

56.898 ± 2.822

14.211 ± 0.675

7.915 ± 0.585

Statistical analysis

p < 0.05

p < 0.05

p < 0.05

p < 0.05

p < 0.05

p < 0.05

Dunnett (2-sided) (significant)

1 & 3

1 & 3

1 & 3

1 & 3

1 & 3

1 & 3

2 & 3

2 & 3

2 & 3

2 & 3

2 & 3

2 & 3