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Table 1 Technical specifications and comparison between the in vitro exposure systems used in this study: Borgwaldt RM20 and Vitrocell VC 10 [40]

From: Application of dosimetry tools for the assessment of e-cigarette aerosol and cigarette smoke generated on two different in vitro exposure systems

  Borgwaldt RM20S smoking machine Vitrocell VC 10 smoking robot
Dimensions (L × D × H) 2.4 m × 0.8 m × 1.3 m 1.5 m × 0.8 m × 0.85 m
Footprint Floor standing (2 m2) Bench top (1.2 m2)
Dilution system Syringe based independent dilution system capable of 8 independent dilutions per exposure device Continuous flow dilution bar capable of 4 independent dilutions per exposure device
Dilution range 1:2–1:4000 (aerosol:air, v/v) Diluting airflow 0–12 l/min and exposure module vacuum sample rate 5–200 ml/min
Exposure throughput Up to 8 chambers with 3, 6, 8 inserts/chamber Up to 4 modules with 3 or 4 inserts/module
Computer controller Integrated computer Requires PC
Smoking regime ISO, HCI, Massachusetts, bell and square (e-cig) puff profiles ISO, HCI and bespoke (human) smoking profiles, bell and square (e-cig) puff profiles
Tubing transit length to exposure device ~290 cm ~90 cm
Time taken from puff to exposure ~15–24 s (depending on dilution) ~8 s