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Table 1 Computed affinity (pKi), cLogP, and ∆G (kcal/mol) for the proposed derivatives

From: Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m

  Compound Affinity (pKi) cLogP ∆G kcal/mol
1 Phenyl 11.38 6.8 −30.54
2 4-Methyl phenyl 11.51 7.49 −40.65
3 4-Hydroxy phenyl 10.37 6.2 −43.40
4 4-Methoxy phenyl 11.50 6.8 −43.45
5 2,4,6-Trimethyl phenyl 13.64 7.7 50.10
6 4-Chloro phenyl 10.55 8.1 −41.75
7 4-Bromo phenyl 10.72 8.4 −41.95
8 4-Fluoro phenyl 10.24 7.1 −42.15
9 Curcumin 8.66 3.85 −30.85
10 Curcumin derivative (E26C) 10.40 7.9 51.65