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Table 1 Structures and Hammett sigma constants of DTTs

From: Further structure–activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents

Entry R1p) [31] R2p) [31] Entry
H H D3T
1a 4-NO2-C6H4 (0.26) H (0) 4a
1b Ethyl (−0.15) H (0) 4b
1c CO2Et (0.50) H (0) 4c
2a H (0) Me (−0.17) 5a
2b H (0) 4-F-C6H4 (0.06) 5b
2c H (0) 4-pyridinyl (0.44) 5c
2d H (0) 2-furanyl (0.02) 5d
3a CO2Et (0.50) NH2 (−0.66) 6a
3b CO2Et (0.50) Me (−0.17) 6b
3c CO2Et (0.50) NHC(O)Me (0.00) 6c
3e 4-Cl-C6H4 (0.12) NH2 (−0.66) 6d
3d SO2Ph (0.68) NH2 (−0.66) 6e
3f CN (0.66) NH2 (−0.66) 6f
3g Cl (0.23) 4-OMe-C6H4 (−0.08) 6g
3h Cl (0.23) C6H5 (−0.01) 6h
3i Cl (0.23) Ethyl (−0.15) 6i