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Table 3 Binding affinity of bromobenzylamine analogues

From: 4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

Compound R σ1 (K i nM) σ2 (K i nM) Selectivity ratio (K i σ21)
9d 2″-NO2 >434 >854 2
9e 4″-Br 2.95 ± 0.57 >854 289