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Table 3 Binding affinity of bromobenzylamine analogues

From: 4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

Compound

R

σ1 (K i nM)

σ2 (K i nM)

Selectivity ratio (K i σ2/σ1)

9d

2″-NO2

>434

>854

2

9e

4″-Br

2.95 ± 0.57

>854

289

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BMC Chemistry

ISSN: 2661-801X

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