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Table 2 Binding affinity of methanol analogues

From: 4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

Compound R σ1 (K i nM) σ2 (K i nM) Selectivity ratio (K i σ21)
8a 4″-F 1.41 ± 0.22 >854 606
8b 3″,4″-Cl2 >434 >854 2
8c 4″-Cl 2.49 ± 0.24 >854 343
8d 2″-NO2 526.53 ± 69 >854 2
8e 4″-Br 5.22 ± 0.3 >854 164
8f 4″-Me 1.45 ± 0.4 >854 589