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Table 2 Binding affinity of methanol analogues

From: 4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

Compound

R

σ1 (K i nM)

σ2 (K i nM)

Selectivity ratio (K i σ21)

8a

4″-F

1.41 ± 0.22

>854

606

8b

3″,4″-Cl2

>434

>854

2

8c

4″-Cl

2.49 ± 0.24

>854

343

8d

2″-NO2

526.53 ± 69

>854

2

8e

4″-Br

5.22 ± 0.3

>854

164

8f

4″-Me

1.45 ± 0.4

>854

589