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Table 5 Application of the proposed approaches for the determination of adapalene in its pharmaceutical Adapalene® gel

From: Determination of adapalene in gel formulation by conventional and derivative synchronous fluorimetric approaches. Application to stability studies and in vitro diffusion test

Parameter Amount taken (ng/mL) First approach at 389 nm Second approach Comparisonmethod [3]  
Amount found (ng/mL) % found Amount found (ng/mL) % found Amount
found
(µg/mL)
 % found
SDSF at 346 nm FDSF at 312.45 nm SDSF at 346 nm FDSF at 312.45 nm
Adapalene® gela 6.0 5.957 99.28 5.932 6.072 98.87 101.20 20.0 100.07
(0.1 % ADP) 8.0 8.082 101.03 7.922 8.026 99.03 100.33 30.0 98.80
Batch # 011371 10.0 10.007 100.07 10.022 9.905 100.22 99.05 40.0 101.03
  12.0 11.900 99.17 11.972 11.986 99.77 99.88   
Mean    99.89    99.47 100.12   99.97
S.D.    0.86    0.63 0.90   1.12
t    0.11    0.75 0.19   
F    1.69    3.11 1.56   
  1. N.B. Each result is the average of three separate determinations
  2. The tabulated t and F values are 2.57 and 9.55, respectively at P = 0.05 [15]
  3. aProduct of Borg Pharmaceutical Ind., Alexandria, Egypt