Optimization and in vitro antiproliferation of Curcuma wenyujin’s active extracts by ultrasonication and response surface methodology

Table 1 Central composite design and results for ultrasonic extraction of curdione, furanodienone, curcumol and germacrone from Curcuma wenyujin

Run	Factors			Curdione (mg g⁻¹)	Furanodienone (mg g⁻¹)	Curcumol (mg g⁻¹)	Germacrone (mg g⁻¹)	Total yield (mg g⁻¹)
Run	X ₁	X ₂	X ₃	Curdione (mg g⁻¹)	Furanodienone (mg g⁻¹)	Curcumol (mg g⁻¹)	Germacrone (mg g⁻¹)	Total yield (mg g⁻¹)
1	2.6	6.5	14	1.53	0.97	0.16	0.24	2.90
2	6	65	14	1.77	1.32	0.21	0.34	3.64
3	4	50	20	1.34	0.90	0.14	0.23	2.61
4	6	65	3.9	1.62	1.04	0.16	0.26	3.08
5	4	80	20	1.73	1.19	0.20	0.31	3.43
6	6	65	24.1	1.84	1.45	0.22	0.38	3.89
7	8	80	20	2.00	1.50	0.25	0.38	4.13
8	4	80	8	1.57	1.18	0.18	0.29	3.22
9	6	39.8	14	1.38	0.74	0.12	0.18	2.42
10	6	65	14	1.87	1.43	0.20	0.36	3.86
11	6	65	14	1.75	1.39	0.22	0.35	3.71
12	9.4	65	14	1.92	1.47	0.25	0.39	4.03
13	8	50	20	1.80	1.29	0.20	0.33	3.62
14	8	80	8	1.83	1.30	0.21	0.33	3.67
15	4	50	8	1.25	0.78	0.12	0.20	2.35
16	6	90.2	14	1.60	1.11	0.16	0.24	3.11
17	8	50	8	1.82	1.17	0.18	0.30	3.47

X ₁ Liquid to solid ratio (mL g⁻¹); X ₂ Ethanol concentration (%); X ₃ Ultrasonic time (min)

ISSN: 2661-801X