Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester

BMC Chemistry

Table 7 Antibacterial effect expressed as MIC and MBC values (mg/mL) of 6a–j

Sample	S. aureus ATCC 25923		S. lutea ATCC 9341		E. coli ATCC 25922		P. aeruginosa ATCC 27853
Sample	MIC^a	MBC^a	MIC^a	MBC^a	MIC^a	MBC^a	MIC^a	MBC^a
6a	2.5	2.5	0.01	0.01	1.25	1.25	2.5	2.5
6b	1.25	2.5	0.03	1.25	2.5	10	2,5	10
6c	0.01	0.01	0.01	0.03	0.03	0.03	5	5
6d	2.5	2.5	0.01	0.03	1.25	5	1.25	1.25
6e	0.01	0.3	0.01	0.01	10	5	5	5
6f	0.07	2.5	0.03	0.15	0.03	0.15	0.03	1.25
6g	2.5	2.5	0.03	1.25	1.25	1.25	2.5	10
6h	2.5	2.5	0.01	0.01	1.25	5	2.5	2.5
6i	0.3	0.3	0.01	0.01	0.1	0.1	0.03	0.6
6j	0.07	0.07	0.01	0.01	0.03	0.03	1.25	1.25
5	2.5	2.5	0.01	0.01	1.25	1.25	1.25	1.25
A	0.0002	0.0005	0.0002	0.0005	0.008	0.016	nt	nt
C	0.008	0.016	0.003	0.006	0.008	0.016	nt	nt

ISSN: 2661-801X