Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors

BMC Chemistry

Table 1 In vitro urease inhibiton activity of compounds 4a–z and 5a–s

Compound	Urease inhibition IC₅₀ ± SEM [µM]	Compound	Urease inhibition IC₅₀ ± SEM [µM]
4a	39.3 ± 0.36	4x	38.5 ± 0.28
4b	34.4 ± 1.57	4y	83.4 ± 1.00
4c	54.2 ± 0.47	4z	39.8 ± 1.38
4d	31.6 ± 0.79	5a	74.5 ± 0.88
4e	27.5 ± 0.12	5b	29.7 ± 0.67
4f	54.2 ± 0.83	5c	61.4 ± 1.12
4g	28.5 ± 0.41	5d	51.3 ± 0.45
4h	40.3 ± 0.32	5e	39.8 ± 0.75
4i	17.6 ± 0.23	5f	106.4 ± 1.49
4j	22.3 ± 0.73	5g	170.7 ± 1.55
4k	25.8 ± 0.23	5h	49.0 ± 0.55
4l	22.7 ± 0.20	5i	210.1 ± 0.29
4m	39.3 ± 0.79	5j	72.6 ± 0.59
4n	41.2 ± 0.58	5k	43.8 ± 0.33
4o	83.0 ± 0.66	5l	17.2 ± 0.44
4p	39.7 ± 0.70	5m	65.9 ± 0.61
4q	24.6 ± 0.42	5n	23.7 ± 0.57
4r	27.5 ± 0.19	5o	34.6 ± 0.79
4s	109.7 ± 1.10	5p	27.4 ± 0.54
4t	142.1 ± 0.64	5q	41.6 ± 0.41
4v	52.2 ± 1.26	5r	82.8 ± 0.72
4w	59.4 ± 0.98	5s	123.2 ± 0.37
STD. Thiourea	21.2 ± 1.3

ISSN: 2661-801X