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Table 1 In vitro urease inhibiton activity of compounds 4az and 5as

From: Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors

Compound Urease inhibition IC50 ± SEM [µM] Compound Urease inhibition IC50 ± SEM [µM]
4a 39.3 ± 0.36 4x 38.5 ± 0.28
4b 34.4 ± 1.57 4y 83.4 ± 1.00
4c 54.2 ± 0.47 4z 39.8 ± 1.38
4d 31.6 ± 0.79 5a 74.5 ± 0.88
4e 27.5 ± 0.12 5b 29.7 ± 0.67
4f 54.2 ± 0.83 5c 61.4 ± 1.12
4g 28.5 ± 0.41 5d 51.3 ± 0.45
4h 40.3 ± 0.32 5e 39.8 ± 0.75
4i 17.6 ± 0.23 5f 106.4 ± 1.49
4j 22.3 ± 0.73 5g 170.7 ± 1.55
4k 25.8 ± 0.23 5h 49.0 ± 0.55
4l 22.7 ± 0.20 5i 210.1 ± 0.29
4m 39.3 ± 0.79 5j 72.6 ± 0.59
4n 41.2 ± 0.58 5k 43.8 ± 0.33
4o 83.0 ± 0.66 5l 17.2 ± 0.44
4p 39.7 ± 0.70 5m 65.9 ± 0.61
4q 24.6 ± 0.42 5n 23.7 ± 0.57
4r 27.5 ± 0.19 5o 34.6 ± 0.79
4s 109.7 ± 1.10 5p 27.4 ± 0.54
4t 142.1 ± 0.64 5q 41.6 ± 0.41
4v 52.2 ± 1.26 5r 82.8 ± 0.72
4w 59.4 ± 0.98 5s 123.2 ± 0.37
STD. Thiourea 21.2 ± 1.3