Anti-leukemia activity of semi-synthetic phenolic derivatives from Polygonum limbatum Meisn.

BMC Chemistry

Table 2 Cytotoxicity of compounds A, B, 1–4 towards sensitive and drug-resistant cancer cell lines and normal cells, as determined by the resazurin assay

Cell lines	Compounds (μM) and degrees of resistance (in brackets)
	Flavonoid derivatives						Doxorubicin
	A	B^#	1	2	3	4	Doxorubicin
CCRF-CEM	7.85 ± 0.82	10.67 ± 0.73	(−)	(−)	18.07 ± 2.04	(−)	0.20 ± 0.06
CEM/ADR5000	15.03 ± 1.02	18.60 ± 2.60	(−)	(−)	19.70 ± 1.86	(−)	195.12 ± 14.30
Degree of resistance^a	(1.91)	(1.74)			(1.09)		(975.60)

^aThe degree of resistance was determined as the ratio of IC₅₀ value of the resistant/IC₅₀ sensitive cell line; 5,7-dihydroxy-3-(1′-hydroxy-1′-phenyl-methyl)-6-methoxy-chroman-4-one (A), 2′,4′-dihydroxy-3′,6′-dimethoxychalcone (B); 5-hydroxy-6-methoxy-7-O-(3′,3′-dimethylprop-2′-enyl)chroman-4-one (1), 5-acetyl-6-methoxy-7-O-(3′,3′-dimethylprop-2′-enyl)chroman-4-one (2), 2′-hydroxy-3′,6′-dimethoxy-4′-O-(3″,3″-dimethylprop-2″-enyl)chalcone (3), 2′-acetyl-3′,6′-dimethoxy-4′-O-(3″,3″-dimethylprop-2″-enyl)chalcone (4).(−):>125 μM; # data previously reported [4]

ISSN: 2661-801X