Scheme 2From: De-novo design, synthesis and evaluation of novel 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as HIV-1 reverse transcriptase inhibitorsSynthesis of final compounds (8a-o), reagents and conditions: (a) DCM, Et3N, 0 °C-rt, 2.5 h; (b) neat, K2CO3, microwave irradiation at 300 W for 2 to 4.5 minBack to article page