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Table 2 The effect of reaction condition on the synthesis of (5a) under various conditionsa

From: Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones

Entry

Solvent b

Catalyst c

Time (min)

Yield d (%)

1

EtOH

Piperidine

180

37

2

EtOH

AcOH

180

43

3

EtOH

p-TSA

180

40

4

AcOH

AcONa

150

46

5

AcOH

H2SO4

120

61

6

EtOH

DBSNa

120

66

7

MeOH

DBSNa

120

64

8

AcOH

DBSNa

60

94

9

H2O

DBSNa

180

trace

  1. a The reaction was carried out with 1-thia-4-azaspiro[4.5]decan-3-one (3) (10 mmol), benzaldehydes (4a) (10 mmol) at room temperature.
  2. b 10 mL solvent.
  3. c 20 mol%.
  4. d Isolated yields.
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BMC Chemistry

ISSN: 2661-801X

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