Table 2 Matrix effect and extraction recovery of galangin and IS in rat plasma (n = 5)
From: Differential systemic exposure to galangin after oral and intravenous administration to rats
Analyte | Peak area (× 10 3 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Set 1 | Set 2 | Set 3 | Matrix effect | Extraction efficiency | ||||||
Mean ± SD | RSD (%) | Mean ± SD | RSD | Mean ± SD | RSD (%) | Mean (%) | RSD (%) | Mean (%) | RSD (%) | |
Galangin (ng/mL) | ||||||||||
15 | 3.44 ± 0.39 | 11.5 | 2.98 ± 0.08 | 2.87 | 1.04 ± 0.11 | 10.4 | 86.6 | 2.87 | 34.8 | 10.4 |
600 | 97.0 ± 5.14 | 5.30 | 86.5 ± 4.48 | 5.19 | 37.8 ± 1.62 | 4.28 | 89.1 | 5.19 | 43.7 | 4.28 |
1200 | 168 ± 16.0 | 9.53 | 147 ± 5.37 | 3.64 | 76.0 ± 3.14 | 4.13 | 87.6 | 3.64 | 51.6 | 4.13 |
IS (ng/mL) | ||||||||||
500 | 279 ± 35.4 | 12.7 | 251 ± 9.52 | 3.79 | 80.0 ± 5.24 | 6.55 | 90.2 | 3.79 | 31.8 | 6.55 |