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Table 1 IC 50 values of hydrocarbon and fluorocarbon triazole-linked alkyl β-D-glucopyranosides 4a-g tested on Jurkat cells a

From: Cytotoxic activity of triazole-containing alkyl β-D-glucopyranosides on a human T-cell leukemia cell line

Compound Alkyl β-D-glucopyranosides b Control surfactants b
4a 4b 4c 4d 4e 4f 4g 5 C14G1 β-OTG C7G1
Hydrophobic tail C 8 H 17 C 10 H 21 C 12 H 25 C 14 H 29 C 16 H 33 C 2 H 4 C 6 F 13 C 2 H 4 C 8 F 17 C 8 H 17 C 14 H 29 C 8 H 17 C 7 H 15
IC 50 value [μM] 1198 171 89 53 24 * * 663 67 163 *
  1. aThe inhibitory concentration 50% (IC50) in μM is defined as the concentration of experimental compound required to inhibited 50% of the conversion of MTS to formazan, as compared with the absorbance produced by untreated cells after 16 h of incubation.
  2. bPlease see Scheme 1 for the chemical structures and corresponding abbreviations for the alkyl β-D-glucopyranosides and the control surfactants.
  3. *Cytotoxicity was <50% at the highest compound concentration tested (2000 μM) and therefore their IC50 values could not be determined.