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Table 2 Cytotoxicity of the studied compounds towards sensitive and drug-resistant cancer cell lines and normal cells as determined by the resazurin assay

From: Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii(Rutaceae)

Cell lines Isolated compounds, doxorubicin and IC50values (δM)
Compounds Doxorubicin
1 2 3 4
CCRF-CEM 0.24 ± 0.01 0.30 ± 0.04 89.09 ± 6.22 49.81 ± 5.04 0.20 ± 0.06
CEM/ADR5000 31.58 ± 3.48 20.37 ± 2.16 63.09 ± 3.75 44.56 ± 3.92 195.12 ± 14.30
MDA-MB231 30.14 ± 4.12 41.38 ± 3.44 >164.61 62.01 ± 7.24 1.10 ± 0.28
MDA-MB231/BCRP 65.01 ± 5.37 113.98 ± 9.82 >164.61 >154.44 7.83 ± 0.47
HCT116 (p53+/+) 42.46 ± 3.22 87.08 ± 7.55 >164.61 119.88 ± 13.14 1.41 ± 0.29
HCT116 (p53+/+) 62.34 ± 4.41 >119.76 >164.61 >154.44 4.06 ± 0.07
U87MG 60.55 ± 7.29 105.19 ± 9.16 >164.61 70.08 ± 6.40 1.06 ± 0.15
U87MG. ΔEGFR 61.84 ± 4.68 115.30 ± 13.78 >164.61 >154.44 6.11 ± 0.57
HepG2 22.37 ± 1.97 26.69 ± 3.15 >164.61 90.77 ± 8.86 3.83 ± 0.94
AML12 >106.92 >119.76 >164.61 >154.44 >73.59