From: Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii(Rutaceae)
Cell lines | Isolated compounds, doxorubicin and IC50values (δM) | ||||
---|---|---|---|---|---|
Compounds | Doxorubicin | ||||
1 | 2 | 3 | 4 | ||
CCRF-CEM | 0.24 ± 0.01 | 0.30 ± 0.04 | 89.09 ± 6.22 | 49.81 ± 5.04 | 0.20 ± 0.06 |
CEM/ADR5000 | 31.58 ± 3.48 | 20.37 ± 2.16 | 63.09 ± 3.75 | 44.56 ± 3.92 | 195.12 ± 14.30 |
MDA-MB231 | 30.14 ± 4.12 | 41.38 ± 3.44 | >164.61 | 62.01 ± 7.24 | 1.10 ± 0.28 |
MDA-MB231/BCRP | 65.01 ± 5.37 | 113.98 ± 9.82 | >164.61 | >154.44 | 7.83 ± 0.47 |
HCT116 (p53+/+) | 42.46 ± 3.22 | 87.08 ± 7.55 | >164.61 | 119.88 ± 13.14 | 1.41 ± 0.29 |
HCT116 (p53+/+) | 62.34 ± 4.41 | >119.76 | >164.61 | >154.44 | 4.06 ± 0.07 |
U87MG | 60.55 ± 7.29 | 105.19 ± 9.16 | >164.61 | 70.08 ± 6.40 | 1.06 ± 0.15 |
U87MG. ΔEGFR | 61.84 ± 4.68 | 115.30 ± 13.78 | >164.61 | >154.44 | 6.11 ± 0.57 |
HepG2 | 22.37 ± 1.97 | 26.69 ± 3.15 | >164.61 | 90.77 ± 8.86 | 3.83 ± 0.94 |
AML12 | >106.92 | >119.76 | >164.61 | >154.44 | >73.59 |