Skip to main content

Table 2 Cytotoxicity of the studied compounds towards sensitive and drug-resistant cancer cell lines and normal cells as determined by the resazurin assay

From: Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii(Rutaceae)

Cell lines

Isolated compounds, doxorubicin and IC50values (δM)

Compounds

Doxorubicin

1

2

3

4

CCRF-CEM

0.24 ± 0.01

0.30 ± 0.04

89.09 ± 6.22

49.81 ± 5.04

0.20 ± 0.06

CEM/ADR5000

31.58 ± 3.48

20.37 ± 2.16

63.09 ± 3.75

44.56 ± 3.92

195.12 ± 14.30

MDA-MB231

30.14 ± 4.12

41.38 ± 3.44

>164.61

62.01 ± 7.24

1.10 ± 0.28

MDA-MB231/BCRP

65.01 ± 5.37

113.98 ± 9.82

>164.61

>154.44

7.83 ± 0.47

HCT116 (p53+/+)

42.46 ± 3.22

87.08 ± 7.55

>164.61

119.88 ± 13.14

1.41 ± 0.29

HCT116 (p53+/+)

62.34 ± 4.41

>119.76

>164.61

>154.44

4.06 ± 0.07

U87MG

60.55 ± 7.29

105.19 ± 9.16

>164.61

70.08 ± 6.40

1.06 ± 0.15

U87MG. ΔEGFR

61.84 ± 4.68

115.30 ± 13.78

>164.61

>154.44

6.11 ± 0.57

HepG2

22.37 ± 1.97

26.69 ± 3.15

>164.61

90.77 ± 8.86

3.83 ± 0.94

AML12

>106.92

>119.76

>164.61

>154.44

>73.59