Table 4 Pharmacokinetic Parameters required for assessment of Montelukast, Gliclazide and Nifedipine Bioavailability

C_max (ng/mL)

882.39 ± 245.8

2917.2 ± 991.3

353.519 ± 104.5

AUC _0–48 (ng.h/mL)

4493.23 ± 2576.3

45156.15 ± 45988.13

1261.81 ± 155.1

AUC _0-α (ng.h/ml)

4797.49 ± 2808.6

49915.8 ± 51881.3

1423.3 ± 295.5

t_max (median) h

4.25

8.00

4.24

t_1/2 (h)

3.86 ± 27

7.24 ± 8.3

2.7 ± 0.36

MRT (h)

7.27 ± 3.7

15.46 ± 11.6

5.88 ± 3.1

K_el (h)

0.282 ± 0.32

0.240 ± 0.17

0.255 ± 0.03