Table 3 Stability and dilution integrity data of linifanib in rat plasma
Stability | Nominal concentration (ng/mL) (n = 6) | Mean ± SD | Precision (% CV) | Accuracy (%) |
|---|---|---|---|---|
Bench top (6 hrs) | 1.28 | 1.35 ± 0.06 | 4.4 | 105.0 |
425 | 393 ± 34.8 | 8.9 | 92.7 | |
Freeze thaw (3 cycle) | 1.28 | 1.30 ± 0.10 | 7.7 | 101.1 |
425 | 385 ± 14.3 | 3.7 | 90.7 | |
In injector (48 hrs) | 1.28 | 1.42 ± 0.09 | 6.3 | 110.6 |
425 | 455 ± 19.8 | 4.4 | 107.2 | |
30 days at −80°C | 1.28 | 1.26 ± 0.10 | 7.9 | 98.3 |
425 | 384 ± 20.2 | 5.3 | 90.5 | |
Dilution integrity | 225 | 226 ± 16.4 | 7.3 | 100.7 |
450 | 444 ± 20.6 | 4.6 | 98.9 |