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Table 3 Stability and dilution integrity data of linifanib in rat plasma

From: Simple, sensitive and rapid determination of linifanib (ABT-869), a novel tyrosine kinase inhibitor in rat plasma by UHPLC-MS/MS

Stability Nominal concentration (ng/mL) (n = 6) Mean ± SD Precision (% CV) Accuracy (%)
Bench top (6 hrs) 1.28 1.35 ± 0.06 4.4 105.0
  425 393 ± 34.8 8.9 92.7
Freeze thaw (3 cycle) 1.28 1.30 ± 0.10 7.7 101.1
  425 385 ± 14.3 3.7 90.7
In injector (48 hrs) 1.28 1.42 ± 0.09 6.3 110.6
  425 455 ± 19.8 4.4 107.2
30 days at −80°C 1.28 1.26 ± 0.10 7.9 98.3
  425 384 ± 20.2 5.3 90.5
Dilution integrity 225 226 ± 16.4 7.3 100.7
  450 444 ± 20.6 4.6 98.9