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Table 1 Experimental matrix and experimental plan of the face centered composite design

From: A validated spectrofluorimetric method for the determination of nifuroxazide through coumarin formation using experimental design

Number of experiments      Experimental variables
  X1 X2 X3 X4 Volume of EAA (ml) Volume of H2SO4(ml) Temperature (°C) Heating time (min)
1 1 0 −1 −1 0.3 1.5 25 10
2 0 1 1 1 0.2 2.5 55 30
3 1 −1 −1 1 0.3 0.5 25 30
4 0 0 0 0 0.2 1.5 40 20
5 −1 1 0 −1 0.1 2.5 40 10
6 −1 0 −1 0 0.1 1.5 25 20
7 0 0 0 0 0.2 1.5 40 20
8 0 −1 1 0 0.2 0.5 55 20
9 1 1 1 −1 0.3 2.5 55 10
10 −1 −1 0 1 0.1 0.5 40 30
11 0 0 0 0 0.2 1.5 40 20