Table 3 Stability and dilution integrity data of LND in rabbit plasma
Stability | Nominal conc. (ng/mL) | Measured conc. (ng/mL ± SD) | Precision (CV,%) | Accuracy (recovery,%) |
|---|---|---|---|---|
Bench top (6 h) | 1.28 | 1.32 ± 0.08 | 6.13 | 103 |
800 | 753 ± 26.24 | 3.50 | 94.1 | |
Freeze thaw (3 cycle) | 1.28 | 1.33 ± 0.05 | 3.77 | 104 |
800 | 767 ± 23.76 | 3.10 | 95.8 | |
In injector (48 h) | 1.28 | 1.32 ± 0.06 | 4.24 | 103 |
800 | 787 ± 38.06 | 4.80 | 98.3 | |
30 days at ̶ 80°C | 1.28 | 1.35 ± 0.04 | 2.79 | 105 |
800 | 752 ± 16.24 | 2.16 | 94 | |
Dilution integrity | 360 | 373 ± 24.80 | 6.60 | 104 |
720 | 681 ± 28.90 | 4.20 | 94.6 |