The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome

Table 1 Statistical tests

Treatment	NDFs^a	WS^a	NDFs / WS^b
MK2.III (5μM)	p > 0.37	p < 0.05	p < 0.029
SB203580 (2.5μM)	p < 0.05	p < 0.036	p < 0.014

^a Probability that inhibitor treatment results in no significant extension of replicative capacity for NDFs or WS fibroblasts compared to DMSO-treated cells (paired t-test).
^b Probability that the extension of replicative capacity seen for WS cells is not greater than that seen for NDFs for same treatment (unpaired 2-tailed t-test).

ISSN: 2661-801X