Table 1 Anti- Candida activity of the target compounds 5a-k against Candida albicans and Candida tropicalis
Compound no | Candida albicans | Candida tropicalis | ||
|---|---|---|---|---|
DIZ ± SD* | MIC (μmol/mL)** | DIZ ± SD* | MIC (μmol/mL)** | |
5a | 17 ± 1.1 | 0.0833 | 13 ± 0.9 | 0.3331 |
5b | 16 ±1.1 | 0.6662 | 14 ±1.0 | 0.3331 |
5c | 16 ±1.0 | 0.6742 | 14 ± 0.9 | 0.3371 |
5d | 14 ± 0.5 | 0.3523 | 16 ±1.1 | 0.3523 |
5e | 16 ±1.6 | 0.3854 | 16 ± 0.6 | 0.3854 |
5f | 16 ± 0.9 | 0.3902 | 11 ± 0.9 | 0.7803 |
5g | 14 ± 0.0 | 0.6678 | 14 ± 0.0 | 0.3339 |
5h | 17 ± 0.9 | 0.4218 | 17 ± 0.8 | 0.4218 |
5i | 14 ± 0.0 | 0.8134 | 16 ± 1.0 | 0.8134 |
5j | 14 ± 0.0 | 0.8134 | 19 ± 1.0 | 0.4067 |
5k | 16 ± 0.6 | 0.7208 | 14 ± 0.5 | 0.3604 |
Fluconazole | 15 ± 0.5 | >1.6325 | 16 ± 0.5 | >1.6325 |