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Table 6 Assay results for the determination of LEV and AMB in their single tablet by the proposed and comparison methods

From: Micellar liquid chromatographic method for the simultaneous determination of Levofloxacin and Ambroxol in combined tablets: Application to biological fluids

Preparation

Proposed method

Comparison method (35)

Amount taken

Amount found

% Found

% Found

(μg/mL)

(μg/mL)

LeeFlox ® tablets (250 mg LEV)

4.0

3.9180

97.97

100.10

20.0

19.9980

99.99

99.02

 

25.0

25.0100

100.04

98.16

X ¯ ± SD

  

99.31 ± 1.22

99.09 ± 0.97

% RSD

  

1.23

0.98

% Error

  

0.71

0.57

t-test

  

0.27 (2.78)

 

F-test

  

1.47 (19.00)

 

Ambroxol® tablets (30 mg AMB)

4.0

4.0800

102.00

100.68

8.0

8.2070

102.59

103.35

 

16.0

16.0360

100.23

101.60

x ¯ ± SD

  

*101.60 ± 1.23

*101.88 ± 1.36

% RSD

  

1.21

1.33

% Error

  

0.70

0.77

t-test

  

0.26 (2.78)

 

F-test

  

1.22 (19.00)

 
  1. N.B. Each result is the average of three separate determinations.
  2. * Figures between parentheses are the tabulated t and F values, respectively at p = 0.05 [38].
  3. Average LEV concentration found in Leeflox tablet 248.275 mg and average AMB found in Ambroxol tablet 30.48 mg.
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BMC Chemistry

ISSN: 2661-801X

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