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Table 6 Assay results for the determination of LEV and AMB in their single tablet by the proposed and comparison methods

From: Micellar liquid chromatographic method for the simultaneous determination of Levofloxacin and Ambroxol in combined tablets: Application to biological fluids

Preparation Proposed method Comparison method (35)
Amount taken Amount found % Found % Found
(μg/mL) (μg/mL)
LeeFlox ® tablets (250 mg LEV) 4.0 3.9180 97.97 100.10
20.0 19.9980 99.99 99.02
  25.0 25.0100 100.04 98.16
X ¯ ± SD    99.31 ± 1.22 99.09 ± 0.97
% RSD    1.23 0.98
% Error    0.71 0.57
t-test    0.27 (2.78)  
F-test    1.47 (19.00)  
Ambroxol® tablets (30 mg AMB) 4.0 4.0800 102.00 100.68
8.0 8.2070 102.59 103.35
  16.0 16.0360 100.23 101.60
x ¯ ± SD    *101.60 ± 1.23 *101.88 ± 1.36
% RSD    1.21 1.33
% Error    0.70 0.77
t-test    0.26 (2.78)  
F-test    1.22 (19.00)  
  1. N.B. Each result is the average of three separate determinations.
  2. * Figures between parentheses are the tabulated t and F values, respectively at p = 0.05 [38].
  3. Average LEV concentration found in Leeflox tablet 248.275 mg and average AMB found in Ambroxol tablet 30.48 mg.
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BMC Chemistry

ISSN: 2661-801X

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