Table 8 Derived pharmacophore model for anticancer activity of acridones active against human cancer cell line MCF-7
Acridones | Score obtained | Categorizing through threshold (S = 4.1274) | Predicted activity | Experimental activity (IC50in μM) | Experimental response |
|---|---|---|---|---|---|
1. | 4.2712 | > 4.1274 | significantly active | 229 | Poor activity |
2. | 3.5826 | < 4.1274 | Non-significant activity | Not tested | Not tested |
3. | 3.6316 | < 4.1274 | Non-significant activity | Not tested | Not tested |
4. | 3.6796 | < 4.1274 | Non-significant activity | >300 | Non active |
5. | 3.3015 | < 4.1274 | Non-significant activity | >300 | Non active |
6. | 2.9402 | < 4.1274 | Non-significant activity | Not tested | Not tested |
7. | 2.4587 | < 4.1274 | Non-significant activity | Not tested | Not tested |
8. | 5.1457 | > 4.1274 | Significantly active | 205 | Poor activity |
9. | 4.9482 | > 4.1274 | Significantly active | Not tested | Not tested |
10. | 5.5092 | > 4.1274 | Significantly active | Not tested | Not tested |