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Table 8 Derived pharmacophore model for anticancer activity of acridones active against human cancer cell line MCF-7

From: Aromatase and glycosyl transferase inhibiting acridone alkaloids from fruits of Cameroonian Zanthoxylumspecies

Acridones Score obtained Categorizing through threshold (S = 4.1274) Predicted activity Experimental activity (IC50in μM) Experimental response
1. 4.2712 > 4.1274 significantly active 229 Poor activity
2. 3.5826 < 4.1274 Non-significant activity Not tested Not tested
3. 3.6316 < 4.1274 Non-significant activity Not tested Not tested
4. 3.6796 < 4.1274 Non-significant activity >300 Non active
5. 3.3015 < 4.1274 Non-significant activity >300 Non active
6. 2.9402 < 4.1274 Non-significant activity Not tested Not tested
7. 2.4587 < 4.1274 Non-significant activity Not tested Not tested
8. 5.1457 > 4.1274 Significantly active 205 Poor activity
9. 4.9482 > 4.1274 Significantly active Not tested Not tested
10. 5.5092 > 4.1274 Significantly active Not tested Not tested
  1. The threshold score (S) of 4.1274 has been selected for the screening of lead compounds.