Approaches towards the synthesis of a novel class of 2-amino-5-arylazonicotinate, pyridazinone and pyrido[2,3- d ]pyrimidine derivatives as potent antimicrobial agents

Table 5 The MICs (μg/mL) of selected newly synthesized compounds against the tested microorganisms

Compound No.	The minimum inhibitory concentration (MIC) in μg/mL
Compound No.	E. coli	P. aeruginosa	B. subtilis	S. aureus	C. albicans
1a	50	-	50	-	12.5
2a	-	-	125	100	-
2g	-	-	100	-	-
8a	-	-	12.5	-	-
8b	-	-	25	-	-
8c	-	-	50	-	-
8d	-		25	-
8e	-	-	25	-	-
8g	-	-	25	-	-
10a	-	-	50	-	-
10b	-	-	25	-	-
10c	-	-	12.5	-	-
11b	-	-	100	-	-
13a	-	-	100	-	-
13b	-	-	100	-	-
15a	-	-	100	-	-
15b	-	-	50	-	-
16	0	0	50	100	-
^a Ampicillin	6.25	-	12.5	12.5	-
^b Cycloheximide	-	-	-	-	-

^a Ampicillin antibacterial drug, ^b cycloheximide antifungal drug, – not measured.

ISSN: 2661-801X