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Table 5 The MICs (μg/mL) of selected newly synthesized compounds against the tested microorganisms

From: Approaches towards the synthesis of a novel class of 2-amino-5-arylazonicotinate, pyridazinone and pyrido[2,3-d]pyrimidine derivatives as potent antimicrobial agents

Compound No.

The minimum inhibitory concentration (MIC) in μg/mL

E. coli

P. aeruginosa

B. subtilis

S. aureus

C. albicans

1a

50

-

50

-

12.5

2a

-

-

125

100

-

2g

-

-

100

-

-

8a

-

-

12.5

-

-

8b

-

-

25

-

-

8c

-

-

50

-

-

8d

-

 

25

-

 

8e

-

-

25

-

-

8g

-

-

25

-

-

10a

-

-

50

-

-

10b

-

-

25

-

-

10c

-

-

12.5

-

-

11b

-

-

100

-

-

13a

-

-

100

-

-

13b

-

-

100

-

-

15a

-

-

100

-

-

15b

-

-

50

-

-

16

0

0

50

100

-

a Ampicillin

6.25

-

12.5

12.5

-

b Cycloheximide

-

-

-

-

-

  1. a Ampicillin antibacterial drug, b cycloheximide antifungal drug, – not measured.
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BMC Chemistry

ISSN: 2661-801X

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