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Table 2 In vitro antitubercular activities of compounds 7f and 7g against MDR strains of M. tuberculosis a (MIC: μg/mL)

From: Synthesis and structure−activity relationship of 8-substituted protoberberine derivatives as a novel class of antitubercular agents

Compd 257/87 373/192 559/262 164/266 H37Rv
7f b 2 4 2 2 2
7g c 0.5 0.25 0.5 1 0.5
RIF > 32 > 32 > 32 > 32 0.0625
INH 2 4 2 2 0.0625
  1. a: MDR strains were isolated from patients with tuberculosis in China.
  2. b: MIC values against MDR strains 257, 373, 559 and 164.
  3. c: MIC values against MDR strains 87, 192, 262 and 266.