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Table 2 In vitro antitubercular activities of compounds 7f and 7g against MDR strains of M. tuberculosis a (MIC: μg/mL)

From: Synthesis and structure−activity relationship of 8-substituted protoberberine derivatives as a novel class of antitubercular agents

Compd

257/87

373/192

559/262

164/266

H37Rv

7f b

2

4

2

2

2

7g c

0.5

0.25

0.5

1

0.5

RIF

> 32

> 32

> 32

> 32

0.0625

INH

2

4

2

2

0.0625

  1. a: MDR strains were isolated from patients with tuberculosis in China.
  2. b: MIC values against MDR strains 257, 373, 559 and 164.
  3. c: MIC values against MDR strains 87, 192, 262 and 266.
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BMC Chemistry

ISSN: 2661-801X

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